Features

Diabetes Test !

Mast Cell !

 Anticancer Molecules !    

Oral Bacteria !

Mouth Ulcer !

Migraines During Menstruation !

Products of SQUARE Pharmaceuticals PLC.

EDITORIAL TEAM

OMAR AKRAMUR RAB

MBBS, FCGP, FIAGP,

P G Dip. Business Management

Rubyeat Adnan

MBBS, MPH, CCD

Mushfiqur Rahman

MBBS

EDITORIAL

Dear Doctor:

Welcome to online bulletin 'e-SQUARE' !

Our current issue focused on some interesting features like

"Diabetes Test !", "Mast Cell !", "Anticancer Molecules !", "Oral Bacteria !", "Mouth Ulcer !", "Migraines During Menstruation !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals PLC. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS PLC.

                                    Chemists synthesize unique anticancer molecules using novel approach

Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters. The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who aimed to recreate these structures from scratch in the laboratory. Researcher has succeeded in synthesizing eight of the compounds for the first time using an approach that combines inventive chemical strategy with the latest technology in small molecule structure determination. These molecules have been an outstanding challenge in the field of synthetic chemistry. A number of research groups have tried to recreate these molecules in the lab, but their structures are so dense, so intricately connected, that it hasn't been possible. In nature, the molecules are found in some species of bryozoa small, aquatic animals that feed by filtering prey from the water via tiny tentacles. Researchers worldwide consider bryozoans to be a potentially valuable source of new medications, and many molecules isolated from bryozoans have been studied as novel anticancer agents. However, the complexity of the molecules often limits their further development. The result of the new approach is eight new synthetic molecules with therapeutic potential and the promise of more new chemistry to come.

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                   Double risk of dementia after mouth ulcer virus

People who have had the herpes virus at some point in their lives are twice as likely to develop dementia compared to those who have never been infected. A new study confirms previous research on whether herpes can be a possible risk factor for dementia. The herpes simplex virus infection is lifelong, but the symptoms can come and go over different periods of life. Many people never get any symptoms linked to their infection. The Scientist said that about this particular study is that the participants are roughly the same age, which makes the results even more reliable since age differences, which are otherwise linked to the development of dementia, cannot confuse the results. 55 million people worldwide are affected by dementia. Advanced age and carrying the Apo lipoprotein risk gene are already known risk factors. Research has previously been conducted to investigate whether the herpes simplex virus could also be a possible risk factor for dementia; something now confirmed in this study. It is exciting that the results confirm previous studies. More and more evidence is emerging from studies that, like our findings, point to the herpes simplex virus as a risk factor for dementia. Important conclusions from the study include the need to further investigate whether already known drugs against the herpes simplex virus can reduce the risk of dementia and the possibility of developing new vaccines. The results may drive dementia research further towards treating the illness at an early stage using common anti-herpes virus drugs, or preventing the disease before it occurs.

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                             Low estrogen levels paired with higher CGRP levels may jump start migraine

As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate. This elevated level of CGRP following hormonal fluctuations could help to explain why migraine attacks are more likely during menstruation and why migraine attacks gradually decline after menopause. The study involved three groups of female participants with episodic migraine. All had at least three days with migraine in the month before the study. The groups were those with a regular menstrual cycle, those taking oral contraceptives, and those who had gone through menopause. Each group was compared to a group of female participants of similar ages who did not have migraine. Each group had 30 people, for a total of 180. Researchers collected blood and tear fluid to determine CGRP levels. In those with regular menstrual cycles, the samples were taken during menstruation when estrogen levels are low and around the time of ovulation, when levels are the highest. In those taking oral contraceptives, samples were taken during the hormone-free time and the hormone-intake time. Samples were taken once from postmenopausal participants at a random time. The study found that female participants with migraine and a regular menstrual cycle had higher CGRP concentrations during menstruation than those without migraine. In contrast, female participants taking oral contraceptives and in postmenopause had similar CGRP levels in the migraine and non-migraine groups. The study also suggests that measuring CGRP levels through tear fluid is feasible and warrants further investigation, as accurate measurement in the blood is challenging due to its very short half-life.

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